Valle Salimbene is situated in the Ticino Valley. Valle Salimbene is located in the Lombard park of the Ticino Valley, in the southern part of the Province; Albuzzano, Cura Carpignano, Linarolo, Pavia and Travacò Siccomario are the adjacent Communes.
It covers an overall area of about 7,1 km² and the hamlets of Busto di Ferro, Motta San Damiano and San Leonardo are part of it.